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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
1 mg	3-5days	￥668.00	登錄后可見	- +
2 mg	3-5days	￥986.00	登錄后可見	- +
5 mg	3-5days	￥1566.00	登錄后可見	- +

規(guī)格

庫存

目錄價

會員專享價

數(shù)量

1 mg

3-5days

￥668.00

登錄后可見

- +

2 mg

3-5days

￥986.00

登錄后可見

- +

5 mg

3-5days

￥1566.00

登錄后可見

- +

基本信息

英文名稱	HRO761 \| Werner syndrome RecQ helicase-IN-1
中文名稱	HRO761 \| Werner syndrome RecQ helicase-IN-1
CAS號	2869954-34-5
分子式	C31H31ClF3N9O5
分子量	702.08
外觀	White to light yellow powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells.

相關(guān)文獻(xiàn)

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.

PMID: 38658754 PMCID: PMC11078746 DOI: 10.1038/s41586-024-07350-y

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CL2980

HRO761 | Werner syndrome RecQ helicase-IN-1

2869954-34-5 98+% 3-5days

￥668.00 1 mg

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HRO761 | Werner syndrome RecQ helicase-IN-1

HRO761 | Werner syndrome RecQ helicase-IN-1

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