英文名稱 | SRT 1720 monohydrochloride |
---|---|
中文名稱 | SRT 1720 HCl |
CAS號(hào) | 2060259-60-9 |
分子式 | C25H23N7OS ·HCl |
分子量 | 506.02 | 469.57(free) |
外觀 | Brown to reddish brown |
儲(chǔ)存條件 | 4°C, stored under nitrogen |
規(guī)格 | 庫(kù)存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 | |
---|---|---|---|---|---|
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英文名稱 | SRT 1720 monohydrochloride |
---|---|
中文名稱 | SRT 1720 HCl |
CAS號(hào) | 2060259-60-9 |
分子式 | C25H23N7OS ·HCl |
分子量 | 506.02 | 469.57(free) |
外觀 | Brown to reddish brown |
儲(chǔ)存條件 | 4°C, stored under nitrogen |
SRT 1720 monohydrochloride is a selective and orally active activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Nature. 2007 Nov 29;450(7170):712-6
re sirtuins viable targets for improving healthspan and lifespan?
PMID: 22653216 PMCID: PMC4684642 DOI: 10.1038/nrd3738
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
PMID: 22546858 PMCID: PMC3366403 DOI: 10.1172/JCI60132
PMID: 25411356 PMCID: PMC4297239 DOI: 10.1158/1535-7163.MCT-14-0584