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依維莫司

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Everolimus | RAD-001

產(chǎn)品編號：CL2331 CAS No.：159351-69-6 MDLNo： 分子式：C53H83NO14 分子量：958.22
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
10 mg In-stock ￥328.00 登錄后可見
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25 mg In-stock ￥568.00 登錄后可見
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基本信息
英文名稱 Everolimus | RAD-001
中文名稱依維莫司
CAS號159351-69-6
分子式C53H83NO14
分子量958.22
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

 Everolimus, also known as RAD001, is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.


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