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氯氮平N-氧化鹽酸

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Clozapine N-oxide dihydrochloride

產(chǎn)品編號：CL2075A CAS No.：2250025-93-3 MDLNo： 分子式：C18H19ClN4O · 2HCl 分子量：415.74 | 342.83(free)

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產(chǎn)品詳情
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基本信息

英文名稱	Clozapine N-oxide dihydrochloride
中文名稱	氯氮平N-氧化鹽酸
CAS號	2250025-93-3
分子式	C18H19ClN4O · 2HCl
分子量	415.74 \| 342.83(free)
外觀	Light yellow to yellow powder
儲存條件	4°C, stored under nitrogen

產(chǎn)品詳情

Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist.

相關(guān)文獻(xiàn)

The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice.

PMID: 29497149 PMCID: PMC5832819 DOI: 10.1038/s41598-018-22116-z

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Novel designer receptors to probe GPCR signaling and physiology.

PMID: 23769625 PMCID: PMC3758874 DOI: 10.1016/j.tips.2013.04.006

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Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity.

PMID: 25822789 PMCID: PMC4476301 DOI: 10.1038/nature14251

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Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs.

PMID: 30038895 PMCID: PMC6053635 DOI: 10.1016/j.mex.2018.03.003

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Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor.

PMID: 31214037 PMCID: PMC6558205 DOI: 10.3389/fphar.2019.00628

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氯氮平 N-氧化物

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氯氮平N-氧化鹽酸

2250025-93-3 98+%

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