英文名稱 | Gemcitabine Base | LY 188011 | NSC 613327 |
---|---|
中文名稱 | 吉西他濱 |
CAS號(hào) | 95058-81-4 |
分子式 | C9H11F2N3O4 |
分子量 | 263.2 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
規(guī)格 | 庫(kù)存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 |
---|---|---|---|---|
500 mg | In-stock | ¥578.00 | 登錄后可見(jiàn) | |
1 g | In-stock | ¥858.00 | 登錄后可見(jiàn) |
英文名稱 | Gemcitabine Base | LY 188011 | NSC 613327 |
---|---|
中文名稱 | 吉西他濱 |
CAS號(hào) | 95058-81-4 |
分子式 | C9H11F2N3O4 |
分子量 | 263.2 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Gemcitabine (formerly LY-188011, NSC-613327; LY188011, NSC613327; dFdC; dFdCyd; trade name: Gemzar), an approved antimetabolite anticancer drug, is a potent DNA synthesis inhibitor with potential antineoplastic activity. With IC50s of 50 nM, 40 nM, 18 nM, and 12 nM, respectively, it suppresses the growth of PANC1, MIAPaCa2, BxPC3, and Capan2 cells. Difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP) are the active metabolites of gemcitabine that are produced intracellularly. The deoxynucleotide pool available for DNA synthesis is reduced when dFdCDP inhibits ribonucleotide reductase.