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格列喹酮

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Gliquidone

產(chǎn)品編號(hào)：CL1154 CAS No.：33342-05-1 MDLNo： 分子式：C27H33N3O6S 分子量：527.63
規(guī)格 庫(kù)存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
250 mg In-stock ￥150.00 登錄后可見
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500 mg In-stock ￥200.00 登錄后可見
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1 g In-stock ￥300.00 登錄后可見
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基本信息
英文名稱 Gliquidone
中文名稱格列喹酮
CAS號(hào)33342-05-1
分子式C27H33N3O6S
分子量527.63
外觀White crystalline powder, odorless
產(chǎn)品詳情

Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.

Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic β-cells (IC50s = 0.45, 119.1, and 149.7 μM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 10 μM in a transactivation assay). Gliquidone (0.2 nmol/g) decreases plasma levels of D-glucose and stimulates insulin release in anesthetized rats.  It decreases blood glucose levels, serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities, and hepatic lipid peroxidation and increases hepatic glutathione (GSH) levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg.


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