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阿貝西利甲磺酸鹽

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Abemaciclib Mesylate | LY2835219 Mesylate) | Abemaciclib Methanesulfonate

產(chǎn)品編號：CL1153 CAS No.：1231930-82-7 MDLNo： 分子式：C28H36F2N8O3S 分子量：602.70
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
5 mg 3-5days ￥566.00 登錄后可見
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10 mg 3-5days ￥1066.00 登錄后可見
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基本信息
英文名稱 Abemaciclib Mesylate | LY2835219 Mesylate) | Abemaciclib Methanesulfonate
中文名稱阿貝西利甲磺酸鹽
CAS號1231930-82-7
分子式C28H36F2N8O3S
分子量602.70
外觀White to yellow powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.


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