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達格列凈

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Dapagliflozin (BMS-512148)

產(chǎn)品編號:CL1127 CAS No.:461432-26-8 MDLNo: 分子式:C21H25ClO6 分子量:408.87
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
500 mg In-stock ¥488.00 登錄后可見
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1 g 3-5days ¥788.00 登錄后可見
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基本信息
英文名稱 Dapagliflozin (BMS-512148)
中文名稱達格列凈
CAS號461432-26-8
分子式C21H25ClO6
分子量408.87
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Dapagliflozin (formerly known as BMS-512148; trade names Farxiga in the US and Forxiga in the EU) is a potent and selective hSGLT2 (sodium-glucose transport proteins) inhibitor with anti-diabetic activity. It inhibits hSGLT2 with an EC50 of 1.1 nM, and exhibits1200-fold selectivity over hSGLT1.  Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2) which are responsible for at least 90% of the glucose reabsorption in the kidney. Urine is the means by which blood glucose is expelled when this transporter mechanism is blocked.

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