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乙酸阿比特龍酯/醋酸阿比特龍

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Abiraterone Acetate (CB7630)

產(chǎn)品編號：CL1079A CAS No.：154229-18-2 MDLNo： 分子式：C26H33NO2 分子量：391.55
規(guī)格 庫存 目錄價(jià) 會員專享價(jià) 數(shù)量
250 mg In-stock ￥150.00 登錄后可見
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500 mg In-stock ￥200.00 登錄后可見
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1 g In-stock ￥350.00 登錄后可見
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5 g In-stock ￥600.00 登錄后可見
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基本信息
英文名稱 Abiraterone Acetate (CB7630)
中文名稱乙酸阿比特龍酯/醋酸阿比特龍
CAS號154229-18-2
分子式C26H33NO2
分子量391.55
外觀 White crystalline powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Abiraterone acetate is an inhibitor of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 17 and 18 nM for inhibition of C17,20-lyase and 17α-hydroxylase activities, respectively).  It is also a prodrug form of abiraterone (Item No.9002768).Abiraterone acetate reduces plasma testosterone levels, increases plasma luteinizing hormone levels, and reduces ventral prostate, seminal vesicle, testis, and kidney weight in mice when administered at doses of 0.1 and 0.5 mmol/kg per day. It also reduces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in the culture supernatant of infected Vero E6 cells (EC90 = 8.4 μM) and is active in a plaque reduction assay (EC50 = 1.94 μM).  Formulations containing abiraterone acetate have been used in combination therapy for the treatment of metastatic castration-resistant prostate cancer.

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